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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Pigmented villonodular synovitis


Other Names for this Disease
  • Diffuse pigmented villonodular synovitis
  • Localized pigmented villonodular synovitis
  • Tenosynovial giant cell tumors
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Overview


Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  There are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  The additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  The average age of diagnosis for this condition is 35 years.[1]
Last updated: 11/28/2011

References

  1. Mendenhall WM, Mendenhall CM, Reith JD, Scarborough MT, Gibbs CP, Mendenhall NP. Pigmented Villonodular Synovitis. American Journal of Clinical Oncology. 2006; 29:548-550. http://www.ncbi.nlm.nih.gov/pubmed/17148989. Accessed 11/22/2011.
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