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Genetic and Rare Diseases Information Center (GARD)

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Liddle syndrome

Other Names for this Disease
  • Liddle's syndrome
  • Pseudoaldosteronism
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What are the signs and symptoms of Liddle syndrome?

Liddle syndrome is chiefly characterized by severe, early-onset hypertension (high blood pressure). In most affected individuals the condition becomes apparent at a young age, but some are not diagnosed until well into adulthood.[1] Individuals typically present with hypertension, hypokalemia (low blood potassium) and metabolic alkalosis.[1] Symptoms of hypokalemia may include weakness, fatigue, muscle pain (myalgia), constipation or heart palpitations.[2] Some affected individuals are not hypokalemic at the time of presentation.[1]
Last updated: 9/21/2012

  1. William F. Young, Jr. Genetic disorders of the collecting tubule sodium channel: Liddle's syndrome and pseudohypoaldosteronism type 1. UpToDate. Waltham, MA: UpToDate; 2012;
  2. Rosa Vargas-Poussou. Liddle syndrome. Orphanet. August 2011; Accessed 9/21/2012.