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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Ollier disease


Other Names for this Disease

  • Dyschondroplasia
  • Enchondromatosis
  • Multiple cartilaginous enchondroses
  • Multiple enchondromatosis
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Overview

Ollier disease is a skeletal disorder characterized by an asymmetric distribution of cartilagenous tumors (endochondromas) which may lead to skeletal deformities and limb-length discrepancy.[1][2][3] This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet (metaphyses).[1][3] Clinical manifestations often appear in the first decade of life. The cause is unknown. There is no medical treatment, although surgery may be indicated in cases where complications (pathological fractures, growth defect, malignant transformation) arise.[3]
Last updated: 5/19/2011

References

  1. Ollier Disease. National Organization for Rare Disorders (NORD). 2006; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/337/viewAbstract. Accessed 5/19/2011.
  2. Chew FS, Maldjian C. Enchondroma and Enchondromatosis. eMedicine. 2009; http://emedicine.medscape.com/article/389224-overview. Accessed 5/19/2011.
  3. Silve C, Juppner H. Ollier disease. Orphanet Journal of Rare Diseases. 2006; http://www.ojrd.com/content/1/1/37. Accessed 5/19/2011.
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Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Ollier disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Dyschondroplasia
  • Enchondromatosis
  • Multiple cartilaginous enchondroses
  • Multiple enchondromatosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.