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Milroy disease

Other Names for this Disease
  • Congenital hereditary lymphedema
  • Early onset lymphedema
  • Hereditary lymphedema
  • Hereditary lymphedema 1
  • Milroy's disease
More Names
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Milroy disease is a lymphatic disease that causes swelling (lymphedema) in the lower legs and feet soon after birth. Other symptoms may include accumulation of fluid in the scrotum, abnormalities of the urethra, upslanting toenails, deep creases in the toes, wart-like growths, prominent leg veins, and cellulitis. Gene mutations in the FLT4 gene cause some cases of Milroy disease, however for many cases the cause of the disorder is unknown.[1]
Last updated: 7/29/2011


  1. Milroy disease. Genetics Home Reference. 2008; Accessed 7/29/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Milroy disease. This website is maintained by the National Library of Medicine.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Milroy disease. Click on the link to view a sample search on this topic.