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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Nephrocalcinosis


Other Names for this Disease

  • Hypercalcemic nephropathy
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Treatment

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How might nephrocalcinosis be treated?

Treatment of nephrocalcinosis includes treating the underlying condition causing nephrocalcinosis, if it is known. The goal of treatment is to reduce symptoms and prevent more calcium from being deposited in the kidneys. Measures are usually taken to reduce abnormal levels of calcium, phosphate, and oxalate in the blood. Medications that cause calcium loss are typically stopped.[1]

Treatment of hypercalcemia (increased calcium levels in the blood) and hypercalcemic nephropathy typically includes adequate hydration by isotonic sodium chloride (normal saline) solution to reverse hypercalcemia and protect the kidneys. Treatment of macroscopic nephrocalcinosis (calcium deposition that is visible without magnification) may include thiazide diuretics and dietary salt restriction; potassium and magnesium supplementation; and citrate supplementation in idiopathic hypercalciuria (of unknown cause) and in distal renal tubular acidosis. Lessening of nephrocalcinosis may occur over time, but in many cases, such as when it results from primary hyperoxaluria or distal renal tubular acidosis, nephrocalcinosis is largely irreversible. Therefore, early detection and treatment are important.[2]

Individuals interested in learning about treatment options for themselves should speak with their health care provider or a nephrologist.
Last updated: 2/24/2011

References
  1. Louis S. Liou, David Zieve. Nephrocalcinosis. PubMed Health. August 30, 2009; http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001522. Accessed 2/24/2011.
  2. Tibor Fulop, Mahendra Agraharkar, Rupert Patel, Rajiv Gupta. Nephrocalcinosis. eMedicine. April 21, 2009; http://emedicine.medscape.com/article/243911-overview. Accessed 2/24/2011.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Nephrocalcinosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Hypercalcemic nephropathy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.