Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Nevoid basal cell carcinoma syndrome


Other Names for this Disease

  • Basal Cell Nevus Syndrome
  • Fifth Phacomatosis
  • Gorlin Syndrome
  • Gorlin-Goltz Syndrome
  • Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

Newline Maker

What are the signs and symptoms of nevoid basal cell carcinoma syndrome?

Many different features have been described in people with nevoid basal cell carcinoma syndrome (NBCCS). These features are highly variable, even within affected members of the same family.[1]

Signs and symptoms in affected people may include:[1]
  • large head size (macrocephaly), large forehead (bossing of the forehead), coarse facial features, and/or facial milia (bumps on the skin that look like clogged pores or whiteheads)
  • skeletal abnormalities of the ribs and/or spine (bifid ribs, wedge-shaped vertebrae)
  • medulloblastoma (childhood brain tumor) in about 5% of affected children
  • multiple jaw keratocysts (usually in the second decade of life)
  • basal cell carcinoma
  • sebaceous and dermoid cysts
  • cardiac and ovarian fibromas
Last updated: 7/16/2014

References
  1. D Gareth Evans and Peter A Farndon. Nevoid Basal Cell Carcinoma Syndrome. GeneReviews. March 7, 2013; http://www.ncbi.nlm.nih.gov/books/NBK1151/. Accessed 7/16/2014.


Other Names for this Disease
  • Basal Cell Nevus Syndrome
  • Fifth Phacomatosis
  • Gorlin Syndrome
  • Gorlin-Goltz Syndrome
  • Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.