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Genetic and Rare Diseases Information Center (GARD)

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Myelodysplastic syndromes

Other Names for this Disease
  • MDS
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Your Question

Is there any information about what genes are on chromosome 20q12 and what those genes do?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What genes are on chromosome 20q12, and what do these genes do?

Deletions of the long arm of chromosome 20, often written as del(20q), occur in less than 5 percent of cases of myelodysplastic syndrome (MDS). Further studies are needed to determine exactly which genes on chromosome 20 are involved in the development of MDS.[1] Chromosome 20 likely contains between 700 and 800 genes, which perform a variety of different roles in the body.[2] Studies suggest that some of the genes may play critical roles in controlling the growth and division of cells.[2]

A map of the genes on chromosome 20q12 can be viewed on the National Center for Biotechnology Information's Web site by clicking here. Alternatively, a more exhaustive list of the genes on chromosome 20q12 can also be viewed on this site by clicking here. Clicking on the name of the gene will lead to a summary of the gene, including any disorders with which it is known to be associated. Unfortunately, there is not currently a "patient-friendly" resource that lists and/or explains all of the genes on chromosome 20q12. A meeting with a genetics professional may be able to offer additional information about these genes and their functions.

Last updated: 3/23/2012

How can I find a genetics professional in my area?

Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:
Last updated: 10/18/2013

  • Yanming Zhang, Michelle M Le Beau. Cytogenetics and molecular genetics of myelodysplastic syndromes. UpToDate. UpToDate; October 11, 2011;
  • Chromosome 20. Genetics Home Reference. April 2010; Accessed 3/23/2012.