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Genetic and Rare Diseases Information Center (GARD)

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Multicentric reticulohistiocytosis

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Your Question

I am in contact with people from around the world with MRH through Facebook.  Many of us have intermittent itching. Can you address this issue? Thank you.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is itchy skin (pruritus) known to be associated with multicentric reticulohistiocytosis?

Yes. It has been estimated that about 1 in 3 people with multicentric reticulohistiocytosis report that they experience pruritus.[1]
Last updated: 6/24/2013

How might itchiness (pruritus) associated with multicentric reticulohistiocytosis be treated?

When severe, pruritus can adversly affect daily living. Managing this symptom is important and may require long-term therapy. While the optimal treatment for multicentric reticulohistiocytosis associated pruritus is not currently known, you may find the following article to be a helpful resource. This article reviews current approaches to treating pruritus associated with paraneoplastic skin diseases. It explores the use of selective serotonin reuptake inhibitors, selective neuroepinephrine re-uptake inhibitors, ultraviolet therapy, and combination therapies for treatment of chronic itch. We recommend that you review this article with your healthcare provider.

Yosipovitch G. Chronic pruritus: a paraneoplastic sign. Dermatol Ther. 2010 Nov-Dec;23(6):590-6. Click on the title to view the full-text article.
Last updated: 6/24/2013