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Genetic and Rare Diseases Information Center (GARD)

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Mixed connective tissue disease

Other Names for this Disease
  • MCTD
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How might mixed connective tissue disorder be treated?

Currently there is not a cure for mixed connective tissue disorder (MCTD), however treatments to help control signs and symptoms of MCTD are available.[1][2] Treatment may involve over the counter or prescription nonsteroidal anti-inflammatory drugs.  Glucocorticoids may be recommended in certain situations, such as during disease flares or should complications of MCTD arise (e.g., aseptic meningitis, myositis, pleurisy, pericarditis, and myocarditis).[1] Some people with MCTD require long term use of immune suppressant medications. The choice of medication is selected based on the patient's symptoms.[1][2] For example, if a person with MCTD has developed symptoms similar to those of lupus, medications typically prescribed for people with lupus may be recommended.[2]

You can find further general information regarding treatment of mixed connective tissue disorder at the following link to the Mayo Foundation for Medical Education and Research Web site:

The Cedars-Sinai Web site also provides information on this topic at the following link:

Last updated: 1/9/2012

  1. Bennett RM. Prognosis and treatment of mixed connective tissue disease. In: Basow, DS (Ed). UpToDate. Waltham, MA: UpToDate; 2012;
  2. Mixed connective tissue disease. Mayo Foundation for Medical Education and Research. February 20, 2010; Accessed 2/9/2012.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Mixed connective tissue disease. Click on the link to go to to read descriptions of these studies.