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Genetic and Rare Diseases Information Center (GARD)

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Mixed connective tissue disease

Other Names for this Disease
  • MCTD
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What causes mixed connective tissue disease?

Mixed connective tissue disease (MCTD) is a term used by some experts to describe a collection of symptoms similar to those of systemic lupus erythematosus, scleroderma, polymyositis, and dermatomyositis. At this time the cause of mixed connective tissue disease is poorly understood. It is an autoimmune disease and there have been many studies looking carefully at how the immune system is involved in patients with this disease.  Click here to learn more about autoimmune diseases.[1][2] 
Last updated: 9/15/2011

  1. Hoffman RW. Mixed Connective Tissue Disease. eMedicine. August 2008; Accessed 9/15/2011.
  2. Wozniacka A, Schwartz RA. Mixed Connective Tissue Disease. eMedicine. September 2009; Accessed 9/15/2011.