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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Mixed connective tissue disease


Other Names for this Disease

  • MCTD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Mixed connective tissue disease (MCTD) is an autoimmune disorder that causes overlapping features of three connective tissue disorders: lupus, scleroderma, and polymyositis. MCTD may also have features of rheumatoid arthritis. This condition is most often diagnosed in women in their 20s and 30s. Occasionally, children are affected.[1] At this time the cause of this condition is unknown. Treatment may involve the use of nonsteroidal anti-inflammatory drugs (NSAIDs), antimalarials, and/or corticosteroids. In cases with severe visceral involvement, additional immunosuppressants may be needed.[2]
Last updated: 6/2/2014

References

  1. Mixed connective tissue disease. Mayo Foundation for Medical Education and Research. February 20, 2010; http://www.mayoclinic.com/health/mixed-connective-tissue-disease/DS00675. Accessed 2/9/2012.
  2. Zahir Amoura and Laurent Arnaud. Mixed connective tissue disease. Orphanet. October, 2009; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=809. Accessed 6/2/2014.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

3 question(s) from the public on Mixed connective tissue disease have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • The Mayo Clinic Web site has an information page on mixed connective tissue disease that can be found at the following link. Click on The Mayo Clinic to view the information page.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • The website TheDoctorsDoctor provides a web page on mixed connective tissue disease that you may find helpful. Click on TheDoctorsDoctor to view the information page.

In Depth Information

  • Medscape Reference has two articles on this topic from the perspective of Pediatrics and Rheumatology. You may need to register to view the information online, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Mixed connective tissue disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • MCTD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.