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Genetic and Rare Diseases Information Center (GARD)

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Melnick-Needles syndrome

Other Names for this Disease
  • Melnick-Needles osteodysplasty
  • MNS
  • Osteodysplasty of Melnick and Needles
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How is Melnick-Needles syndrome inherited?

This condition is inherited in an X-linked dominant pattern. This means that the gene associated with this condition is located on the X chromosome, which is one of the two sex chromosomes. In females (who have two X chromosomes), a mutation in one of the two copies of the gene in each cell is sufficient to cause the disorder.  A female with this condition has a 50% chance of passing the X chromosome with the mutation to each of her children. In males (who have only one X chromosome and a Y chromosome), a mutation in the only copy of the gene in each cell causes the disorder. A male with this condition will always pass the X chromosome with the mutation to each of his daughters, but fathers cannot pass X-linked traits to their sons.[1]
Last updated: 11/3/2010

  1. Melnick-Needles syndrome. Genetics Home Reference. November 2007; Accessed 11/2/2010.