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Genetic and Rare Diseases Information Center (GARD)

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Melkersson-Rosenthal syndrome

Other Names for this Disease
  • Cheilitis Granulomatosa
  • Melkersson syndrome
  • MROS
  • MRS
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Your Question

What is the incidence of Melkersson-Rosenthal syndrome? How many cases have been reported in India? 

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is Melkersson-Rosenthal syndrome?

Melkersson-Rosenthal syndrome is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips, and the development of folds and furrows in the tongue. Onset is in childhood or early adolescence. After recurrent attacks, swelling may persist and increase, eventually becoming permanent. The lip may become hard, cracked, and fissured with a reddish-brown discoloration. The cause of Melkersson-Rosenthal syndrome is unknown, but there may be a genetic predisposition. It can be symptomatic of Crohn's disease or sarcoidosis.[1]
Last updated: 7/18/2011

What is the incidence of Melkersson-Rosenthal syndrome?

Melkersson-Rosenthal syndrome has an estimated incidence of 8/10,000.[2]
Last updated: 7/18/2011

How many cases of Melkersson-Rosenthal syndrome have been reported in India?

Unfortunately for the rare diseases, specific statistical data is often lacking.  There is simply no official method for tracking these conditions. Our review of the medical literature identified at least 9 reported cases of Melkersson-Rosenthal syndrome in India.

You can view references related to these cases through PubMed, a searchable database of biomedical journal articles. Although not all of the articles are available for free online, most articles listed in PubMed have a summary available. To obtain the full article, contact a medical/university library or your local library for interlibrary loan. You can also order articles online through the publisher’s Web site. Using 'melkersson rosenthal syndrome AND India' as your search term should help you locate articles. Use the advanced search feature to narrow your search results. Click here to view a search.

The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.

Last updated: 7/18/2011