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Genetic and Rare Diseases Information Center (GARD)

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Melkersson-Rosenthal syndrome


Other Names for this Disease

  • Cheilitis Granulomatosa
  • Melkersson syndrome
  • MROS
  • MRS
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Overview

Melkersson-Rosenthal syndrome is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips, and the development of folds and furrows in the tongue. Onset is in childhood or early adolescence. After recurrent attacks, swelling may persist and increase, eventually becoming permanent. The lip may become hard, cracked, and fissured with a reddish-brown discoloration. The cause of Melkersson-Rosenthal syndrome is unknown, but there may be a genetic predisposition. It can be symptomatic of Crohn's disease or sarcoidosis.[1]
Last updated: 7/18/2011

References

  1. NINDS Melkersson-Rosenthal Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). 2007; http://www.ninds.nih.gov/disorders/melkersson/melkersson.htm. Accessed 7/18/2011.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Melkersson-Rosenthal syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Cheilitis Granulomatosa
  • Melkersson syndrome
  • MROS
  • MRS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.