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Diseases

Genetic and Rare Diseases Information Center (GARD)

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McCune Albright syndrome

Información en español

Other Names for this Disease

  • Albright syndrome
  • Albright's disease
  • MAS
  • PFD
  • POFD
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Cause

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What causes McCune Albright syndrome?

McCune Albright syndrome (MAS) is caused by a change (mutation) in the GNAS gene. This gene provides instructions for making part of a protein that ultimately influences many cell functions by regulating hormone activity. GNAS gene mutations that cause MAS result in a protein that causes the enzyme adenylate cyclase to be constantly turned on. This, in turn, leads to over-production of several hormones, resulting in the signs and symptoms of MAS.[1]
Last updated: 1/2/2014

References
  1. McCune-Albright syndrome. Genetics Home Reference (GHR). January 2009; http://ghr.nlm.nih.gov/condition=mccunealbrightsyndrome. Accessed 10/17/2013.


Other Names for this Disease
  • Albright syndrome
  • Albright's disease
  • MAS
  • PFD
  • POFD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.