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Genetic and Rare Diseases Information Center (GARD)

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Marchiafava Bignami disease

Other Names for this Disease
  • Acute Marchiafava-Bignami disease
  • Chronic Marchiafava-Bignami syndrome
  • MBD
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What are the signs and symptoms of Marchiafava Bignami disease?

Most individuals diagnosed with Marchiafava Bignami disease (MBD) have a history of alcoholism and poor nutrition. How onset occurs (suddenly or chronically) and the range of clinical symptoms vary among affected individuals.[1] Generally, the most common presentation includes personality change and psychomotor impairment.[2] Some individuals present to the hospital with sudden onset of stupor or coma, and some present with seizures. Other individuals may have acute, subacute, or chronic onset of dementia and/or gait problems. Psychiatric disturbances, incontinence, hemiparesis, aphasia, and apraxia have also been described.[1]
Last updated: 12/7/2012

  1. Jennifer Ault. Marchiafava-Bignami Disease. eMedicine. February 3, 2010; Accessed 5/31/2011.
  2. Kumar N. Neurologic presentations of nutritional deficiencies. Neurol Clin. February 2010; 28(1):107-170.