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Genetic and Rare Diseases Information Center (GARD)

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Marchiafava Bignami disease

Other Names for this Disease
  • Acute Marchiafava-Bignami disease
  • Chronic Marchiafava-Bignami syndrome
  • MBD
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What causes Marchiafava Bignami disease?

The exact cause of Marchiafava Bignami disease is not known. Alcoholism seems to be the greatest risk factor for the disease, although rare cases have occurred in individuals who did not drink alcohol. Nutritional factors have been suspected, but no specific nutrient has been identified.[1] Other possible causes include electrolyte disturbances or direct toxicity of ethanol or other substances.[2][1]
Last updated: 6/1/2011

  1. Jennifer Ault. Marchiafava-Bignami Disease. eMedicine. February 3, 2010; Accessed 5/31/2011.
  2. Walter G. Bradley et al. Neurology in Clinical Practice, 5th ed.. USA: Butterworth-Heinemann; 2008 ;