Marchiafava Bignami disease
Other Names for this Disease
- Acute Marchiafava-Bignami disease
- Chronic Marchiafava-Bignami syndrome
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demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimes progress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, is unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism.Marchiafava Bignami disease is defined by characteristic
Last updated: 6/1/2011
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