Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Mantle cell lymphoma


Other Names for this Disease

  • Lymphoma, mantle cell
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

What is Mantle cell lymphoma?

What are the signs and symptoms of Mantle cell lympoma?

What causes Mantle cell lymphoma?

How is Mantle cell lymphoma diagnosed?

How might Mantle cell lympoma be treated?

What is Mantle cell lymphoma?

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-Hodgkin’s lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. [1][2][3] Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone.[4] Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.[2][3]
Last updated: 7/20/2011

What are the signs and symptoms of Mantle cell lympoma?

Common symptoms of Mantle cell lymphoma include fatigue, loss of appetite, and enlarged lymph nodes, spleen, and/or liver. Other symptoms may include night sweats, unexplained high fevers, and weight loss.[2]
Last updated: 7/20/2011

What causes Mantle cell lymphoma?

Most lymphomas are not inherited, but rather an acquired disease in which the DNAwithin the cells has been damaged.[2] Damage to the DNA occurs by a combination of different factors. Many mantle cell lymphomas are found to be associated with a chromsosome translocation. Some causes of non-Hodgkin lymphomas (NHL) have been linked to viral infections including Ebstein-Barr virus, HIV, and human herpesvirus 6. It has also been found that immunodeficiencies and environmental factors like hair dyes and pesticides may lead to NHLs.[5]
Last updated: 7/21/2011

How is Mantle cell lymphoma diagnosed?

Mantle cell lymphoma is diagnosed by a biopsy (surgical removal) of the lymph nodes. If lymph nodes are not easily accessible to be biopsied, a fine needle aspiration may be performed, but the diagnosis will not be definite.[1][2] Chromosome translocations in Mantle cell lymphoma can be found by genetic molecular testing methods such as PCR and FISH.[1]
Last updated: 7/21/2011

How might Mantle cell lympoma be treated?

Various treatmentsare currently available for Mantle cell lymphomas. Rare cases of early stage mantle cell lymphomas may be treated with radiation therapy. [3] For more advance stagestreatment includes chemotherapy, immunotherapy, bone marrow transplant, and medication. [3]
Last updated: 7/21/2011

References
  1. Mantle Cell Lymphomas. Lymphomation. June 2011; http://www.lymphomation.org/type-MCL.htm. Accessed 7/11/2011.
  2. O’Connor OA and Vose JM. Mantle Cell Lymphoma: Getting the Facts. Lymphoma Research Foundation.. http://www.lymphoma.org/atf/cf/%7B0363CDD6-51B5-427B-BE48-E6AF871ACEC9%7D/MANTLE%20CELL.PDF. Accessed 7/11/2011.
  3. Non Hodgkin Lymphoma. American Cancer Society. October 2010; http://www.cancer.org/acs/groups/cid/documents/webcontent/003126-pdf.pdf. Accessed 7/11/2011.
  4. Mantle Cell Lymphoma. National Organization for Rare Disorders (NORD). February 2011; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Mantle%20Cell%20Lymphoma. Accessed 7/11/2011.
  5. Abassi MR. Mantle Cell Lymphoma. Medscape Reference. http://emedicine.medscape.com/article/203085. Accessed 7/18/2011.


Other Names for this Disease
  • Lymphoma, mantle cell
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.