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Malignant hyperthermia

Other Names for this Disease
  • Anesthesia related hyperthermia
  • Fulminating hyperpyrexia
  • Hyperpyrexia malignant
  • Malignant hyperpyrexia
  • MH
More Names
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Malignant hyperthermia is a severe reaction to particular drugs used during surgery and other invasive procedures. People at increased risk for this disorder are said to have malignant hyperthermia susceptibility. If given these drugs, these people may experience muscle rigidity, breakdown of muscle fibers, a high fever, increased acid levels in the blood and other tissues, and a rapid heart rate. Without prompt treatment, the complications of malignant hyperthermia can be life-threatening. There are at least six forms of malignant hyperthermia susceptibility, which are associated with mutations in different genes (e.g.,  CACNA1S, RYR1). The susceptibility is inherited in an autosomal dominant fashion.[1] People with certain inherited muscle diseases (e.g., central core disease and multiminicore disease) also have malignant hyperthermia susceptibility.
Last updated: 4/4/2011


  1. Malignant Hyperthermia. Genetics Home Reference. 2007; Accessed 4/4/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Malignant hyperthermia. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Malignant hyperthermia. Click on the link to view a sample search on this topic.