Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Madelung disease


Other Names for this Disease

  • Benign symmetrical lipomatosis
  • Familial symmetric lipomatosis
  • Launois-Bensaude syndrome
  • Madelung's disease
  • Multiple symmetric lipomatosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Madelung disease is a rare condition characterized by the growth of fatty tumors (lipomas) symmetrically around the neck, shoulders, upper arms and/or upper trunk.[1] It most often affects men of Mediterranean ancestry between the ages of 30 and 70 who have a history of alcohol abuse. Non-alcoholics and women can also be affected. The signs and symptoms, and the disease progression, vary greatly from person to person.[2] Usually, accumulation of fatty tissue increases progressively and often leads to a loss of neck mobility and pain.[3] There may be a period of rapid growth of the tumors followed by a period of stabilization. The lipomas can cause cosmetic deformity and peripheral neuropathy. In the majority of cases, the disease is benign; however, there have been cases in which lipomas have become cancerous.[2] The exact cause of Madelung disease is unknown but may be associated with mutations in mitochondrial DNA and/or alcoholism.[3] Treatment may include avoiding alcohol, medications to correct associated metabolic conditions and surgery or liposuction to remove the lipomas.[2]
Last updated: 6/28/2013

References

  1. Madelung's Disease. NORD. April 1, 2005; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/778/viewAbstract.
  2. Ramos S, Pinheiro S, Diogo C, Cabral L, Cruzeiro C. Madelung Disease. Annals of Plastic Surgery. 2009;
  3. Marie-Christine Vantyghem. Familial symmetric lipomatosis. Orphanet. October 2006; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=2398. Accessed 6/28/2013.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

2 question(s) from the public on Madelung disease have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • The Cushing's Help and Support has created an information page on Madelung disease. To view the information page, click on the link.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.¬†
  • Orphanet is a European reference portal for¬†information on rare diseases and orphan drugs.¬† Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Madelung disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Benign symmetrical lipomatosis
  • Familial symmetric lipomatosis
  • Launois-Bensaude syndrome
  • Madelung's disease
  • Multiple symmetric lipomatosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.