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Genetic and Rare Diseases Information Center (GARD)

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Light chain deposition disease

Other Names for this Disease
  • Light-chain deposition disease
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Your Question

Is light chain deposition disease a genetic/inheritable disease?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is light chain deposition disease?

Light chain deposition disease involves our immune system. It is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. Immunoglobulins, also known as antibodies, are special proteins made by immune cells. While an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. Early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome.[1] Light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes.[2]
Last updated: 4/2/2010

Is light chain deposition disease a genetic/inheritable disease?

Currently, we are not aware of inherited genes or genetic factors that would increase a person’s risk for developing light chain deposition disease.

You can read more about risk factors for multiple myeloma and monoclonal gammopathy of undetermined significance at the following links to the Website.

Multiple myeloma risk factors:

Monoclonal gammopathy of undetermined significance risk factors:

Last updated: 4/2/2010

  • Appel GB. Glomerular disorders and nepharotic syndromes. In: Goldman. Cecil Medicine, 23rd ed. Philadelphia, PA: Saunders; 2007;
  • Jayamohan Y, Sacher RA. Light-chain deposition disease. eMedicine. 2008; Accessed 4/2/2010.