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Genetic and Rare Diseases Information Center (GARD)

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Laron syndrome

Other Names for this Disease
  • Growth hormone insensitivity syndrome
  • Growth hormone receptor deficiency
  • Laron dwarfism
  • Laron type pituitary dwarfism I
  • Pituitary dwarfism II
More Names
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Your Question

My grandson has the condition. I want to know if there is medication that will result in a normal stature.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might Laron syndrome be treated?

Treatment for individuals with Laron syndrome mainly aims at improving growth.[1] The only specific treatment available for this condition is subcutaneous injections of insulin-like growth factor 1 (a growth-promoting hormone), often called IGF-1. IGF-1 stimulates linear growth (height) and improves brain growth as well as the metabolic abnormalities caused by long-term IGF-1 deficiency. It has also been shown to raise blood glucose levels, reduce cholesterol, increase muscle growth, and give other benefits.[2] The growth resulting from IGF-1 treatment is less than what is typically seen with human growth hormone (hGH) treatment in children with growth hormone deficiency. Treatment with IGF-1 reportedly stimulates growth by about 8cm in the first year and 4-5cm in the following years,[3] but more studies on the long-term effects on final height are needed. IGF-1 and GH levels should be closely monitored in individuals undergoing this treatment, because overdosage of IGF-I causes a variety of health problems.[4] Infants may also need frequent feedings in order to avoid hypoglycemia.[1]
Last updated: 11/3/2011

  • J. Léger. Laron syndrome. Orphanet. November 2009; Accessed 11/2/2011.
  • Zvi Laron. Growth Hormone Insensitivity (Laron Syndrome). Reviews in Endocrine & Metabolic Disorders. 2002; 3:347-355.
  • Laron Z. The essential role of IGF-I: lessons from the long-term study and treatment of children and adults with Laron syndrome. J Clin Endocrinol Metab. December 1999; 84(12):4397-4404.
  • Laron Z. Insulin-like growth factor-I treatment of children with Laron syndrome (primary growth hormone insensitivity). Pediatr Endocrinol Rev. March 2008; 5(3):766-771.