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Genetic and Rare Diseases Information Center (GARD)

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Lambert Eaton myasthenic syndrome


Other Names for this Disease
  • Eaton Lambert syndrome
  • Lambert Eaton syndrome
  • LEMS
  • Myasthenic syndrome of Lambert-Eaton
  • Myasthenic-Myopathic syndrome of Lambert-Eaton
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Overview


Lambert Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction. The neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles.[1] This syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. It may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. Symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth.[1] Treatment of a underlying disorder or cancer is the first priority of treatment.
Last updated: 4/22/2011

References

  1. NINDS Lambert-Eaton Myasthenic Syndrome Information Page. Institute of Neurological Disorders and Stroke (NINDS). 2007; http://www.ninds.nih.gov/disorders/lambert_eaton/lambert_eaton.htm. Accessed 10/28/2009.
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