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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Krabbe leukodystrophy


Other Names for this Disease

  • Galactocerebrosidase deficiency
  • Galactosylceramide beta-galactosidase deficiency
  • GALC deficiency
  • GCL
  • GLD
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Prognosis

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What is the prognosis for Krabbe leukodystrophy?

Infantile Krabbe disease is generally fatal before age 2. Prognosis may be significantly better for children who receive umbilical cord blood stem cells prior to disease onset or early bone marrow transplantation. Persons with juvenile- or adult-onset cases of Krabbe disease generally have a milder course of the disease with a slower rate of progression and live significantly longer. Symptoms and signs of the juvenile and adult forms of the disease include spasticity, dementia, ataxia, peripheral neuropathy, and loss of vision.[1][2] 
Last updated: 4/11/2014

References
  1. NINDS Krabbe Disease Information Page. National Institute of Neurological Disorders and Stroke (NINDS). June 2011; http://www.ninds.nih.gov/disorders/krabbe/krabbe.htm. Accessed 7/21/2011.
  2. N P S Bajaj, A Waldman, R Orrell et al. Familial adult onset of Krabbe's disease resembling hereditary spastic paraplegia with normal neuroimaging. J Neurol Neurosurg Psychiatry. November 8, 2001; 72(5):635-638. http://jnnp.bmj.com/content/72/5/635.full. Accessed 4/11/2014.


Other Names for this Disease
  • Galactocerebrosidase deficiency
  • Galactosylceramide beta-galactosidase deficiency
  • GALC deficiency
  • GCL
  • GLD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.