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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Krabbe leukodystrophy


Other Names for this Disease

  • Galactocerebrosidase deficiency
  • Galactosylceramide beta-galactosidase deficiency
  • GALC deficiency
  • GCL
  • GLD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

If a couple has a child with Krabbe leukodystrophy, what is the likelihood of having another child with the condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How is Krabbe leukodystrophy inherited?

Krabbe leukodystrophy is inherited in an autosomal recessive manner. If both parents are carriers (each having one working copy of the gene and one non-working copy), each child that they have has a 25% chance (1 in 4) of being affected (having the condition), a 50% chance (1 in 2) of being an asymptomatic carrier (like each parent), and a 25% chance of being unaffected (not having the condition) and also not being a carrier. If a sibling of a child with Krabbe leukodystrophy is already known to be unaffected, the chance of him/her being a carrier is 2/3.[1]
Last updated: 11/23/2010

How can I find a genetics professional in my area?

Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:
Last updated: 6/5/2014

References
Other Names for this Disease
  • Galactocerebrosidase deficiency
  • Galactosylceramide beta-galactosidase deficiency
  • GALC deficiency
  • GCL
  • GLD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.