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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Kikuchi disease


Other Names for this Disease
  • Histiocytic necrotising lymphadenitis
  • Kikuchi necrotizing lymphadenitis
  • Kikuchi's disease
  • Kikuchi-Fujimoto's disease
  • Nosocomial Kikuchi's disease
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Overview



What is Kikuchi disease?

How might Kikuchi disease be treated?

What is the prognosis for individuals with Kikuchi disease?


What is Kikuchi disease?

Kikuchi disease is a benign (non-cancerous), acute disorder of the lymph nodes that is usually seen in younger women. It is characterized by cervical lymphadenopathy (tender, swollen lymph nodes), mild fever, and night sweats. Less frequent symptoms include weight loss, nausea, vomiting, and sore throat.[1] While the exact cause of this condition is unknown, infectious and autoimmune causes have been proposed.[2] Treatment is symptomatic and supportive and may include pain relievers, non-steroidal anti-inflammatory (NSAIDS) drugs and, rarely, corticosteroids. Most cases resolve spontaneously within 1 to 6 months.[1][2]
Last updated: 4/6/2011

How might Kikuchi disease be treated?

Kikuchi disease is typically self-limited, resolving on its own within one to four months. However, treatment may relieve some of the signs and symptoms of the condition. Analgesics-antipyretics (drugs that relieve pain and fever) and nonsteroidal anti-inflammatory drugs (NSAIDs) may be used to alleviate lymph node tenderness and fever. The use of corticosteroids has been recommended in severe extranodal or generalized Kikuchi disease. Affected individuals should be followed for several years to rule out the development of systemic lupus erythematosus (SLE).[3]

Additional information on the treatment of Kikuchi disease is available on Medscape Reference's Web site and can be viewed by clicking here.
Last updated: 12/12/2012

What is the prognosis for individuals with Kikuchi disease?

Kikuchi disease is generally an acute condition with a favorable prognosis. About 3 to 4% of patients experience recurrence. Lymphadenopathy usually resolves within 1-6 months after onset, although it may persist longer.[1][2]

Some patients go on to develop systemic lupus erythematous (SLE) years later.[1][2] SLE is a chronic autoimmune disorder that may affect the skin, joints, kidneys, and other organs. Symptoms vary from person to person. Almost all people with SLE have joint pain and swelling. Some develop arthritis. Frequently affected joints are the fingers, hands, wrists, and knees. Other common symptoms include chest pain when taking a deep breath, general discomfort or ill feeling, and mouth sores.[4]
Last updated: 4/6/2011

References
  1. Bosch X & Guilabert A. Kikuchi-Fujimoto disease. Orphanet. 2006; http://www.ojrd.com/content/1/1/18 . Accessed 4/6/2011.
  2. Boone J, Kuzma CS. Kikuchi Disease. eMedicine. 2009; http://emedicine.medscape.com/article/210752-overview. Accessed 4/6/2011.
  3. Xavier Bosch and Antonio Guilabert. Kikuchi-Fujimoto disease. OJRD. 2006; 1:18:http://www.ojrd.com/content/1/1/18. Accessed 12/12/2012.
  4. Borigini MJ. Systemic lupus erythematosus. MedlinePlus. February 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm. Accessed 4/6/2011.