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Genetic and Rare Diseases Information Center (GARD)

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Holt-Oram syndrome

Other Names for this Disease
  • Atrio digital syndrome
  • Atriodigital dysplasia
  • Cardiac-limb syndrome
  • Heart-hand syndrome
  • Heart-hand syndrome, type 1
More Names
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Your Question

I would like to know if heart-hand syndrome is associated with mental retardation. What is the normal lifespan of people with this condition?

Our Answer

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Is intellectual disability a feature of Holt-Oram syndrome?

Intellectual disability (formerly known as mental retardation) is not considered to be a feature of Holt-Oram syndrome.[1] This condition is characterized by congenital heart defects and skeletal abnormalities of the upper limbs.[2]
Last updated: 8/9/2010

What is the normal life expectancy for people with Holt-Oram syndrome?

Life expectancy for Holt-Oram syndrome varies among affected individuals and largely depends on the severity of the congenital heart defect.[2]
Last updated: 8/9/2010