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Genetic and Rare Diseases Information Center (GARD)

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Chronic hiccups

Other Names for this Disease
  • Hiccups, intractable
  • Intractable hiccups
  • Intractable singultus
  • Persistent hiccups
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Your Question

My friend has chronic hiccups. His doctors have discovered tumors near his phrenic nerve and suspect that this may be the cause. They have recommended a number of different drug therapies, but nothing has worked. Has there been others with cases like his?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Are lesions or tumors near the phrenic nerve a common cause of chronic hiccups?

The causes of chronic hiccups are many and varied. Hiccups can occur in association with more than 100 medical conditions. Unfortunately, in many cases the underlying cause is never determined.[1] Our search did identify the following case report which describes a person with chronic hiccups due to a schwannoma, a type of nerve sheath tumor, on the phrenic nerve. Click on the title to view the article summary. We recommend that your friend review this information with his healthcare provider.

Gilani SM, Danforth RD. Intractable hiccups: a rare presentation of phrenic nerve schwannoma. Eur Ann Otorhinolaryngol Head Neck Dis. 2012 Dec;129(6):331-3. 
Last updated: 6/21/2013