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Genetic and Rare Diseases Information Center (GARD)

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Essential thrombocythemia

Other Names for this Disease
  • Essential thrombocytosis
  • Hemorrhagic thrombocythemia
  • Idiopathic thrombocythemia
  • Primary thrombocythemia
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Your Question

Is the use of Adderall®, Wellbutrin®, Xanax®, Zoloft®, Ambien®, or Deplin® associated with essential thrombocythemia?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is essential thrombocythemia?

Essential thrombocythemia belongs to a group of conditions called myeloproliferative disorders. Myeloproliferative disorders cause platelets, white blood cells and red blood cells to grow abnormally in the bone marrow (the soft tissue inside the hollow part of bones that helps form blood cells). In essential thrombocythemia, the body produces too many platelet cells. The signs and symptoms vary from person to person, with up to two-thirds of patients not having any symptoms when the platelet cell count first increases. Signs and symptoms may include significant increased production of megakaryocyte (a cell in the bone marrow that is responsible for making platelets), enlargement of the spleen (splenomegaly), and bleeding and/or clotting episodes.[1][2]
Last updated: 6/30/2011

Is the use of Adderall®, Wellbutrin®, Xanax®, Zoloft®, Ambien®, or Deplin® associated with essential thrombocytosis?

We are not aware of an association between the use of these drugs and essential thrombocytosis. Little is known about the cause of essential thrombocythemia. It is known that the condition starts with a change (mutation) in the DNA of a single cell in the bone marrow. The single cell clones itself; therefore, those other cells inherit the same mutation in their DNA. The cause for the DNA change in the first cell is unknown.[1]

If you have questions or concerns regarding these drugs we recommend that you speak with your healthcare provider. You can also visit the following links to, a Web site designed by the National Library of Medicine to help people research health questions, for more information about these medicines, including possible side effects.

Dextroamphetamine and Amphetamine (Adderall®)

Bupropion (Wellbutrin®)

Alprazolam (Xanax®)

Sertraline (Zoloft®)

Zolpidem (Ambien®)

General information on Deplin can be found by visitng the following link to the American Association of Retired Persons (AARP) Web site:

Last updated: 1/28/2010