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Genetic and Rare Diseases Information Center (GARD)

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Factor XII deficiency


Other Names for this Disease

  • Coagulation factor 12 deficiency
  • F12 deficiency
  • Factor 12 deficiency
  • HAF deficiency
  • Hageman factor deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. While a lack of factor XII does not cause affected individuals to bleed abnormally, the blood takes longer than normal to clot in a test tube. The condition is usually discovered when prolonged clotting is noticed in the process of running other laboratory tests.[1] Factor XII deficiency is caused by mutations in the F12 gene. It is inherited in an autosomal recessive manner.[2] 
Last updated: 6/24/2011

References

  1. Dugdale DC, Chen YB. Factor XII (Hageman factor) deficiency. MedlinePlus. 2011; http://www.nlm.nih.gov/medlineplus/ency/article/000545.htm. Accessed 6/24/2011.
  2. Factor XII Deficiency. Online Mendelian Inheritance in Man (OMIM). 2010; http://www.ncbi.nlm.nih.gov/omim/234000. Accessed 6/24/2011.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Factor XII deficiency. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Coagulation factor 12 deficiency
  • F12 deficiency
  • Factor 12 deficiency
  • HAF deficiency
  • Hageman factor deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.