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Genetic and Rare Diseases Information Center (GARD)

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Granulomatous rosacea


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Overview



What is granulomatous rosacea?

What are the symptoms of granulomatous rosacea?


What is granulomatous rosacea?

Granulomatous rosacea is a variant of rosacea, a chronic skin condition involving inflammation of the cheeks, nose, chin, forehead, or eyelids.[1][2][3] Rosacea may appear as redness, prominent spider-like blood vessels, swelling, or skin eruptions similar to acne.[3] Granulomatous rosacea appears to be a distinctive papular form of rosacea that is found primarily across the upper part of the face, particularly around the eyes and the nose. These discrete papules may appear as yellowish-brown hard nodules, and may be accompanied by marked erythema.[1][2][4] Granulomatous rosacea can often be difficult to differentiate from other facial granulomatous dermatoses of unknown cause, especially lupus miliaris disseminatus faciei (LMDF).[2] Granulomatous rosacea has been reported primarily in middle-aged women, and in association with immunosuppression and constitutes about 10% of all cases of rosacea.[1][2] This pattern of rosacea is sometimes associated with scarring and may be resistant to conventional treatment.[4] 
Last updated: 4/26/2010

What are the symptoms of granulomatous rosacea?

Granulomatous rosacea is characterized by hard, yellow, brown, or red cutaneous papules or nodules that may be severe and lead to scarring. These lesions tend to be less inflammatory than papules and pustules and sit upon relatively normal-appearing skin. They can vary in size among patients but are the same in each individual patient, and typically appear on the cheeks and periorificial areas. The presence of other rosacea signs is not needed for a diagnosis of the granulomatous rosacea variant.[5]
Last updated: 4/26/2010

References
  1. Khikhar O, Khachemoune A. Dermatology Online Journal. 2004; http://dermatology.cdlib.org/101/case_reports/rosacea/khachemoune.html. Accessed 4/26/2010.
  2. Kaur S, Kanwar AJ, Thami GP, Mohan H, Arya SK. 2003; http://www.ijdvl.com/article.asp?issn=0378-6323;year=2003;volume=69;issue=7;spage=58;epage=60;aulast=Kaur. Accessed 4/26/2010.
  3. Vorvick LJ. Rosacea. MedlinePlus. November 1, 2009; http://www.nlm.nih.gov/medlineplus/ency/article/000879.htm. Accessed 4/26/2010.
  4. Banasikowska AK, Singh S. Rosacea. eMedicine. June 12, 2009; http://emedicine.medscape.com/article/1071429-overview. Accessed 4/26/2010.
  5. Wilkin J, Dahl M, Detmar M, et al.. Journal of the American Academy of Dermatology. April 2002; http://www.rosacea-research.org/rosacea_classification.htm. Accessed 4/26/2010.