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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Glucose-6-phosphate dehydrogenase deficiency


Other Names for this Disease

  • G6PD deficiency
  • Hemolytic anemia due to G6PD deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

If glucose 6 phosphate dehydrogenase is needed to metabolize carbohydrates and it's missing, then what happens to the sugar in the blood?  Where does it go?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What happens to the sugar in the blood if glucose 6 phosphate dehydrogenase is missing?

Blood sugar or "glucose" is made when carbohydrates are broken down. Glucose-6-phosphate dehydrogenase is one enzyme involved in the pentose phosphate pathway, a pathway which processes glucose. The main reasons for this pathway is actually not to metabolize dietary sugars but to make ribose-5-phosphate which is important for making DNA and RNA, and to make NADPH which is important for protecting cells from potentially harmful molecules called reactive oxygen species. There are other enzymatic pathways in the body that exist to metabolize dietary sugars, for example the Krebb cycle, so when there is a deficiency of glucose-6-phosphate dehydrogenase the primary concern is for the impact the defeciency may have on the body as a result of a lack of ribose-5-phosphate and NADPH, and not necessarily its affect on blood sugar.[1]

To learn more about how your body metabolizes food visit the Nemours: Kids Health Web site resource page on this topic at the following link:
http://kidshealth.org/parent/general/body_basics/metabolism.html
Last updated: 1/7/2010

References
  • Luzzatto L, Mehta A, Vulliamy T. Glucose 6-Phosphate Dehydrogenase Deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B. The Metabolic & Molecular Bases of Inherited Disease 8th ed. New York, NY: McGraw-Hill; 2001;
Other Names for this Disease
  • G6PD deficiency
  • Hemolytic anemia due to G6PD deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.