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Genetic and Rare Diseases Information Center (GARD)

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Focal segmental glomerulosclerosis

Other Names for this Disease
  • Focal sclerosis with hyalinosis
  • Focal segmental glomerulosclerosis 1
  • FSGS
  • FSGS1
  • Glomerulosclerosis, focal
More Names
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Your Question

Does protein S deficiency have anything to do with FSGS? My doctor can not find a cause for my FSGS.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is focal segmental glomerulosclerosis?

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney.[1] FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling.[2][3] In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).[3]  The goal of treatment is to control symptoms and prevent chronic kidney failure.[1] Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.[1]
Last updated: 8/16/2011

Are focal segmental glomerulosclerosis and protein S deficiency associated?

Protein S deficiency is a disorder that causes abnormal blood clotting. We found very limited information in our search of the literature regarding any association between protein S deficiency and FSGS.
Last updated: 8/16/2011