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Genetic and Rare Diseases Information Center (GARD)

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Gardner syndrome


Other Names for this Disease
  • Gardner's syndrome
  • Intestinal polyposis, osteomas, sebaceous cysts
  • Polyposis coli and multiple hard and soft tissue tumors
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Your Question

I was diagnosed with Gardner syndrome at birth.  I had a total colectomy with illeoanal reservoir.  Since the surgery, I have had several orthopedic issues with my spine and shoulder which cause my joints to be extremely flexible, often resulting in catastrophic problems from a minor injury.  I also have had two spinal issues, so at the age of 30 I am looking at permanent pain management therapy as a possibility.  I also have days where I am just completely out of gas by about 1 pm or can't go to work.  My dad's side of the family is the same way - we all have this disorder.  Is all this related to Gardner syndrome?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is Gardner syndrome associated with joint issues?

Though joint issues are not considered a feature of Gardner syndrome, one study found that 5 out of 25 patients with familial adenomatous polyposis (FAP, which is a disorder similar to Gardner syndrome) experienced joint symptoms.  In four of the five patients, these symptoms began following colon surgery.[1]
Last updated: 7/7/2011

Does Gardner syndrome cause exhaustion?

Exhaustion is not considered a direct feature of Gardner syndrome.  However, treatment of Gardner syndrome includes complete removal of the colon, which causes a change in bowel and dietary habits.  This change can alter the absorption of nutrients and potentially lead to vitamin deficiencies that may affect how much energy one feels they have.[2][3]
Last updated: 7/7/2011

References
  • Andreyev HJ, Kamm MA, Forbes A, Nicholls RJ. Joint symptoms after restorative proctocolectomy in ulcerative colitis and familial polyposis coli. Journal of Clinical Gastroenterology. 1996; 23:35-39. http://www.ncbi.nlm.nih.gov/pubmed/8835897. Accessed 7/6/2011.
  • Half E, Bercovich D, Rozen P. Familial adenomatous polyposis. Orphanet journal of rare diseases. 2009; 4:22. http://www.ncbi.nlm.nih.gov/pubmed/19822006. Accessed 7/6/2011.
  • Almendingen K, Fausa O, Høstmark AT, Bratlie J, Mørkerid L, Aabakken L, Vatn MH. Serum nutrients and habitual dietary intake in colectomized FAP patients in Norway. European Journal of Nutrition. 2009; 48:129-136. http://www.ncbi.nlm.nih.gov/pubmed/19142564. Accessed 7/6/2011.