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Genetic and Rare Diseases Information Center (GARD)

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Gardner-Diamond syndrome

Other Names for this Disease
  • Autoerythrocyte sensitization
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Psychogenic purpura
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What are the signs and symptoms of Gardner-Diamond syndrome?

Individuals affected with Gardner-Diamond syndrome have reported that bruises occur either spontaneously or after trauma or surgery at other sites of the body. Some individuals are able to pinpoint exactly when the bruising occurred, while others are not.[1] Episodes may begin with sensations that include burning, stinging, or pain which may be accompanied by a general feeling of malaise or fatigue.[1][2] This may be followed by warmth, puffiness, redness and/or itching in the affected area(s) of the body. In some cases, the development of the bruises may also be accompanied by various things including fever, headache, or gastrointestinal symptoms. Individuals have reported that the pain generally subsides when bruises appear. Sometimes, the pain and swelling may be very severe, causing the affected body part to become immobilized.[1] Bruises typically disappear in approximately 7-10 days.[2] In the majority of affected individuals, relapses and remissions of bruising episodes can last for many years. In some cases, symptoms of the condition persist and may worsen. Subsequent episodes are most likely to occur after some sort of physical trauma or stress.[2]
Last updated: 9/14/2011

  1. Benjamin P Geisler, Bruce J Dezube. Psychogenic purpura (Gardner-Diamond syndrome). UpToDate. January 19, 2011; Accessed 9/12/2011.
  2. OL Ivanov, AN Lvov, AV Michenko, J Künzel, P Mayser, U Gieler. Autoerythrocyte sensitization syndrome (Gardner–Diamond syndrome): review of the literature. Journal of the European Academy of Dermatology and Venereology. 2009; 23(5):499-504.