Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Gardner-Diamond syndrome


Other Names for this Disease

  • Autoerythrocyte sensitization
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Psychogenic purpura
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Cause

Newline Maker

What causes Gardner-Diamond syndrome?

The cause of Gardner-Diamond syndrome is not understood. It is generally accepted that episodes associated with the syndrome are provoked by stress (hence why it is also called psychogenic purpura). However, it is unclear exactly how stress causes the symptoms of the condition.[1] Other mechanisms that have been proposed to play a role in causing the condition include:[2]
  • an increase in the local activity of a specific protein involved in the breakdown of blood clots (tissue plasminogen activator), which can cause a cascade of events that may lead to bleeding
  • an autoimmune reaction to the affected individual's own red blood cells (erythrocytes)
Last updated: 9/12/2011

References
  1. OL Ivanov, AN Lvov, AV Michenko, J Künzel, P Mayser, U Gieler. Autoerythrocyte sensitization syndrome (Gardner–Diamond syndrome): review of the literature. Journal of the European Academy of Dermatology and Venereology. 2009; 23(5):499-504.
  2. Benjamin P Geisler, Bruce J Dezube. Psychogenic purpura (Gardner-Diamond syndrome). UpToDate. January 19, 2011; http://www.uptodate.com/contents/psychogenic-purpura-gardner-diamond-syndrome. Accessed 9/12/2011.


Other Names for this Disease
  • Autoerythrocyte sensitization
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Psychogenic purpura
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.