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Genetic and Rare Diseases Information Center (GARD)

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Gardner-Diamond syndrome

Other Names for this Disease
  • Autoerythrocyte sensitization
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Psychogenic purpura
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What causes Gardner-Diamond syndrome?

The cause of Gardner-Diamond syndrome is not understood. It is generally accepted that episodes associated with the syndrome are provoked by stress (hence why it is also called psychogenic purpura). However, it is unclear exactly how stress causes the symptoms of the condition.[1] Other mechanisms that have been proposed to play a role in causing the condition include:[2]
  • an increase in the local activity of a specific protein involved in the breakdown of blood clots (tissue plasminogen activator), which can cause a cascade of events that may lead to bleeding
  • an autoimmune reaction to the affected individual's own red blood cells (erythrocytes)
Last updated: 9/12/2011

  1. OL Ivanov, AN Lvov, AV Michenko, J Künzel, P Mayser, U Gieler. Autoerythrocyte sensitization syndrome (Gardner–Diamond syndrome): review of the literature. Journal of the European Academy of Dermatology and Venereology. 2009; 23(5):499-504.
  2. Benjamin P Geisler, Bruce J Dezube. Psychogenic purpura (Gardner-Diamond syndrome). UpToDate. January 19, 2011; Accessed 9/12/2011.