Fragile X syndrome
Other Names for this Disease
- Fra(X) syndrome
- FRAXA syndrome
- Marker X syndrome
- Martin-Bell syndrome
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Your QuestionAre individuals with Fragile X syndrome at a higher risk for fractures than individuals without Fragile X?
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Fragile X syndrome is characterized by developmental problems, including delayed development of speech and language, and mild to moderate intellectual disability. Usually, males are more severely affected than females. Additional features may include anxiety and hyperactive behavior such as fidgeting or impulsive actions, attention deficit disorder (ADD), features of autism spectrum disorders that affect communication and social interaction, and seizures. Most males and about half of females with fragile X syndrome have characteristic physical features that become more apparent with age. These features include a long and narrow face, large ears, a prominent jaw and forehead, unusually flexible fingers, flat feet, and in males, enlarged testicles (macroorchidism) after puberty.
Last updated: 6/5/2013
A comprehensive search of the resources available to us did not identify a heighted risk for fractures among individuals with Fragile X syndrome. However, other skeletal and connective tissue problems may be present, including flat feet (pes planus), soft velvet-like skin, joint hypermobility (especially in the fingers), congenital hip dislocation, scoliosis, and clubfoot.
Last updated: 6/5/2013
- Fragile X syndrome. Genetics Home Reference (GHR). April 2012; http://www.ghr.nlm.nih.gov/condition/fragile-x-syndrome. Accessed 6/5/2013.
- Hershe JH, Saul RA. Health Supervision for Children With Fragile X Syndrome. Pediatrics. May 1, 2011; http://pediatrics.aappublications.org/content/127/5/994.full.pdf+html. Accessed 6/5/2013.
- Fragile X Syndrome. National Fragile X Foundation. 2013; http://www.fragilex.org/fragile-x-associated-disorders/fragile-x-syndrome/. Accessed 6/5/2013.