Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Fragile X syndrome

Información en español

Other Names for this Disease

  • Fra(X) syndrome
  • FRAXA syndrome
  • FXS
  • Marker X syndrome
  • Martin-Bell syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

Are individuals with Fragile X syndrome at a higher risk for fractures than individuals without Fragile X?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What are the symptoms of Fragile X syndrome?

Fragile X syndrome is characterized by developmental problems, including delayed development of speech and language, and mild to moderate intellectual disability. Usually, males are more severely affected than females. Additional features may include anxiety and hyperactive behavior such as fidgeting or impulsive actions, attention deficit disorder (ADD), features of autism spectrum disorders that affect communication and social interaction, and seizures. Most males and about half of females with fragile X syndrome have characteristic physical features that become more apparent with age. These features include a long and narrow face, large ears, a prominent jaw and forehead, unusually flexible fingers, flat feet, and in males, enlarged testicles (macroorchidism) after puberty.[1]
Last updated: 6/5/2013

Are individuals with Fragile X syndrome at a higher risk for fractures than individuals without Fragile X?

A comprehensive search of the resources available to us did not identify a heighted risk for fractures among individuals with Fragile X syndrome. However, other skeletal and connective tissue problems may be present, including flat feet (pes planus), soft velvet-like skin, joint hypermobility (especially in the fingers), congenital hip dislocation, scoliosis, and clubfoot.[2][3]
Last updated: 6/5/2013

References
Other Names for this Disease
  • Fra(X) syndrome
  • FRAXA syndrome
  • FXS
  • Marker X syndrome
  • Martin-Bell syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.