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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Fox-Fordyce disease


Other Names for this Disease

  • Apocrine miliaria
  • Fox-Fordyce syndrome
  • Miliaria, apocrine
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Treatment

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How might Fox-Fordyce disease be treated?

Individuals with Fox-Fordyce disease should consult with a dermatologist regarding treatment. Some of the recent treatments for the FFD include:  interlesional glucocorticoids, topical steroids, oral and topical retinoids, topical clindamycin, topical pimecrolimus cream, benzoyl peroxide, oral antibiotics and contraceptives or antiandrogenic hormonal therapy.[1][2]  Pimecrolimus and tacrolimus, both with significant anti-inflammatory activity and low side-effects, have provided rapid improvement in a limited number of cases.[3]  Other forms of treatment used are ultraviolet radiation (phototherapy), dermabrasion, liposuction and surgical excision.[1]  Immunosuppressants have been utilized with modest success.  For individuals who do not respond to medications, destruction or removal of the apocrine sweat glands (glands that surround hair follicles) has been effective in some cases. [1]
Last updated: 8/1/2014

References
  1. Yost, J., Robinson, M., & Meehan, S. A. Fox-Fordyce disease. Dermatology online journal. 2012; 18(12):http://escholarship.org/uc/item/6km4c88v. Accessed 7/31/2014.
  2. Fox-Fordyce disease. In: Oakley A. DermNet NZ. New Zealand: DermNet New Zealand Trust; 2014; http://www.dermnetnz.org/hair-nails-sweat/fox-fordyce.html. Accessed 7/31/2014.
  3. White SW, Gorman CR. Fox-Fordyce Disease. eMedicine. January 12, 2007; http://emedicine.medscape.com/article/1070560-overview. Accessed 3/30/2009.


Other Names for this Disease
  • Apocrine miliaria
  • Fox-Fordyce syndrome
  • Miliaria, apocrine
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.