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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Floating-Harbor syndrome


Other Names for this Disease
  • FHS
  • Pelletier-Leisti syndrome
  • Short stature with delayed bone age, expressive language delay, a triangular face with a prominent nose and deep-set eyes
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What information can you provide about Floating-Harbor syndrome?

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What is Floating-Harbor syndrome?

Floating-Harbor syndrome is a genetic disorder that was named for the first two identified patients who were seen at Boston Floating Hospital and Harbor General Hospital in California.[1][2] The main characteristics of this syndrome are short stature, delayed bone growth, delay in expressive language, and distinct facial features.[1] The exact cause of Floating-Harbor syndrome is not known.[1][2] Treatment is symptomatic and supportive.[1]
Last updated: 5/7/2009

What characteristics have been associated with Floating-Harbor syndrome?

Floating-Harbor syndrome is characterized by short stature, delayed language skills (particularly expressive langauge), delayed bone growth, and a triangular shaped face. A broad nose, deep-set eyes and a wide mouth with thin lips give an affected individual a distinct appearance.[1][2]

Other possible manifestations of this condition include:[1]

Last updated: 5/7/2009

What causes Floating-Harbor syndrome?

The exact cause of Floating-Harbor syndrome is not known.[1] Autosomal dominant inheritance has been suggested.[3] 
Last updated: 5/7/2009

How might Floating-Harbor syndrome be treated?

Treatment for Floating-Harbor syndrome is symptomatic and supportive. For example, dental problems and cataracts may be surgically corrected and sign language and/or speech therapy may help with delays in expressive language.[1]

Additional management strategies may be obtained from the Floating Harbor Syndrome Support Group at:
http://www.floatingharborsyndromesupport.com/ or 336-492-2641.
Last updated: 5/7/2009

References