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Genetic and Rare Diseases Information Center (GARD)

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Fatal familial insomnia


Other Names for this Disease

  • Familial fatal insomnia
  • Insomnia familial fatal
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Overview

Fatal familial insomnia (FFI) is a type of genetic prion disease, also known as a transmissible spongiform encephalopathy (TSE).[1] Prion diseases are progressive, neurodegenerative disorders that may affect humans and animals.[2] The first symptoms of FFI usually begin in mid-life and may include insomnia that worsens over time and vivid dreams when sleep is achieved. These symptoms may be followed by high blood pressure; episodes of hyperventilation; excessive tearing; and/or sexual and urinary tract dysfunction. Other nervous system abnormalities then follow, and affected people develop ataxia (loss of muscle control) over a period of months. FFI usually leads to death within a few months to a few years. Genetic prion diseases are inherited in an autosomal dominant manner and may be caused by mutations in the PRNP gene. Treatment aims at alleviating symptoms when possible.[3]
Last updated: 7/3/2014

References

  1. Fatal Familial Insomnia. Online Mendelian Inheritance in Man (OMIM). 2010; http://www.ncbi.nlm.nih.gov/omim/600072. Accessed 7/26/2010.
  2. Prion disease. Genetics Home Reference (GHR). 2007; http://ghr.nlm.nih.gov/condition/prion-disease. Accessed 7/26/2010.
  3. James A Mastrianni. Genetic Prion Diseases. GeneReviews. January 2, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1229/. Accessed 7/3/2014.
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  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fatal familial insomnia. Click on the link to view a sample search on this topic.

Insurance Issues

Other Names for this Disease
  • Familial fatal insomnia
  • Insomnia familial fatal
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.