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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Fatal familial insomnia


Other Names for this Disease
  • Familial fatal insomnia
  • Insomnia familial fatal
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Overview


Fatal familial insomnia is a prion disorder showing autosomal dominant inheritance.[1] Prion diseases belong to group of progressive conditions that affect the nervous system in humans and animals.[2] Fatal familial insomnia is characterized by insomnia with or without a diurnal dreaming state, hallucinations, delirium, and dysautonomia preceding motor and cognitive deterioration.[1]. To date, there is no treatment of the underlying pathological mechanisms of the disease.[3] The signs and symptoms typically begin in adulthood and lead to death within 6 to 32 months.[2][3]
Last updated: 7/26/2010

References

  1. Fatal Familial Insomnia. Online Mendelian Inheritance in Man (OMIM). 2010; http://www.ncbi.nlm.nih.gov/omim/600072. Accessed 7/26/2010.
  2. Prion disease. Genetics Home Reference (GHR). 2007; http://ghr.nlm.nih.gov/condition/prion-disease. Accessed 7/26/2010.
  3. Brande JP. Fatal familial insomnia. Orphanet. August 2004; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=466. Accessed 7/26/2010.
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Basic Information

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fatal familial insomnia. Click on the link to view a sample search on this topic.

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