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Genetic and Rare Diseases Information Center (GARD)

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Familial idiopathic basal ganglia calcification


Other Names for this Disease

  • Bilateral striopallidodentate calcinosis
  • BSPDC
  • Cerebral calcification nonarteriosclerotic idiopathic adult-onset
  • Fahr disease, familial (formerly)
  • Ferrocalcinosis, cerebrovascular
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

How can I obtain information about treatment options for familial idiopathic basal ganglia calcification (FIBGC)? Is there any research being done to find a treatment or cure for this condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is familial idiopathic basal ganglia calcification (FIBGC)?

Familial idiopathic basal ganglia calcification (FIBGC) is a neurodegenerative disorder characterized by calcium deposits in the basal ganglia, a part of the brain that helps start and control movement. The first symptoms often include clumsiness, fatigue, unsteady walking (gait), slow or slurred speech, difficulty swallowing (dysphagia) and dementia. Seizures of various types frequently occur. Symptoms typically start in an individual's 20's to 40's but may begin at any age.The neuropsychiatric symptoms and movement disorders worsen over time.[1] Mutations in the SLC20A2 and PDGFRB genes have been found to cause FIBGC, and this condition is inherited in an autosomal dominant manner.[2]
Last updated: 10/18/2013

How might familial idiopathic basal ganglia calcification (FIBGC) be treated?

There is no standard course of treatment for FIBGC. Treatment typically addresses symptoms on an individual basis. Medications may be used to improve anxiety, depression, obsessive-compulsive behaviors, and dystoniaAntiepileptic drugs (AEDs) can be prescribed for seizures. Oxybutynin may be prescribed for urinary incontinence (loss of bladder control). Surveillance typically includes yearly neurologic and neuropsychiatric assessments.[1]
Last updated: 8/2/2013

Is there any research being done to find a treatment or cure for familial idiopathic basal ganglia calcification (FIBGC)?

The National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. While no studies specific to treatment for FIBGC are listed at this time, there is a study enrolling patients with various inherited neurological disorders. To find more information about this trial, click here.
Last updated: 11/18/2010

References
Other Names for this Disease
  • Bilateral striopallidodentate calcinosis
  • BSPDC
  • Cerebral calcification nonarteriosclerotic idiopathic adult-onset
  • Fahr disease, familial (formerly)
  • Ferrocalcinosis, cerebrovascular
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.