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Genetic and Rare Diseases Information Center (GARD)

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Evans syndrome

Other Names for this Disease
  • Autoimmune hemolytic anemia and autoimmune thrombocytopenia
  • Evan syndrome
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Your Question

I was first diagnosed with idiopathic thrombocytopenic purpura, which then progressed to Evans syndrome. I had a splenectomy and have since been in remission. My husband and I have been together for 10 years, and in this time I have not conceived. Can Evans syndrome cause infertility? If I do get pregnant, would there be a chance my child could have the same condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can Evans syndrome cause infertility?

A review of available literature does not yield any information or case reports about Evans syndrome and infertility. Furthermore, infertility is not mentioned as being a sign or symptom of Evans syndrome in various resources.

Evans syndrome appears to be rare in pregnancy, with only a few published cases. Concerns about the teratogenic effect (effects harmful to the development of the fetus) of medications used in the management of Evans syndrome can limit the treatment options in pregnancy. But with appropriate treatment, women with Evans syndrome can have successful pregnancies, with a good response to conventional treatment. More detailed studies of Evans syndrome in pregnancy, especially of fetal outcome, are needed.[1]
Last updated: 4/24/2011

Can idiopathic thrombocytopenic purpura be inherited?

The cause of idiopathic thrombocytopenic purpura (ITP) is unknown. It is not thought to be genetic because it is rare for multiple people in the same family to develop this disease.[2] Only a few cases of familial ITP have been documented, including an affected woman and 3 of her 4 children, identical twins with chronic ITP, and a mother with chronic ITP who had a child with purpura. The child's purpura resolved on its own within 3 weeks while the mother remained thrombocytopenic.[3]
Last updated: 1/22/2013

What causes Evans syndrome and can it be inherited?

The specific cause of Evans syndrome is unknown and it has been speculated that for every case, the cause may be different. No genetic causes for Evans syndrome have been identified, and familial occurrence of Evans syndrome is rare.[4][5]
Last updated: 9/22/2011