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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Evans syndrome


Other Names for this Disease

  • Autoimmune hemolytic anemia and autoimmune thrombocytopenia
  • Evan syndrome
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Symptoms

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What are the signs and symptoms of Evans syndrome?

The signs and symptoms of Evans syndrome vary from person to person and largely depend on which blood cells are affected (i.e. platelets, white blood cells, or red blood cells). People with Evans syndrome may have problems with one, two or all three of these different blood cells. If there is a decrease in the number of mature red blood cells, people typically experience anemia, which results in weakness, fatigue, and shortness of breath. With low platelets, affected individuals are susceptible to bleeding and major bruising from minor bumps and cuts. A bump on the head can cause severe brain hemorrhage (bleeding) and even death. With low white blood cells, a person has increased susceptibility to infections and difficulty in fighting these infections.[1]
Last updated: 9/22/2011

The Human Phenotype Ontology provides the following list of signs and symptoms for Evans syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Autoimmune thrombocytopenia -
Autosomal recessive inheritance -
Coombs-positive hemolytic anemia -
Spastic paraplegia -

Last updated: 9/2/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. What is Evans Syndrome?. Evans Syndrome Research and Support . http://www.evanssyndrome.org/#evans. Accessed 9/21/2011.


Other Names for this Disease
  • Autoimmune hemolytic anemia and autoimmune thrombocytopenia
  • Evan syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.