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Other Names for this Disease
- Primary erythermalgia
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Your QuestionI have been diagnosed with erythromelalgia, and received a prescription for mexiletine. I noticed on the patient information sheet that it said that this medication is an anti-arrhythmic used to treat irregular heartbeat. Have you heard about mexiletine being used for erythromelalgia?
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Erythromelalgia (EM), is a rare disorder that is characterized by episodes of burning pain, warmth, and redness in the hands and feet. The cause of the symptoms in erythromelalgia is unknown.
Last updated: 5/30/2012
Although we cannot provide medical or treatment advise we have been able to research documenting the use of mexiletine as a treatment option for erythromelagia. Mexiletine is an oral medication is often paired with intravenous lidocaine for the treatment of erythromelagia. Local anesthetics such as lidocaine and mexiletine prevent or relive pain in erythromelagia by interrupting nerve conduction. Mexiletine is an oral analog of lidocaine (both IB antiarrythmia drugs) that share the ability to block the sodium channel.
Last updated: 7/9/2013
PubMed lists journal articles that discuss the treatment of erythromelalgia with mexiletine. Click on the link to go to PubMed and review citations to these articles.
Last updated: 2/19/2008
- Davis MD. NORD Guide to Rare Disorders. Erythromelalgia. Philadelphia: Lippincott Williams & Wilkins; 2003; 113-114.
- Kuhnert SM, Phillips WJ, Davis MD. Lidocaine and Mexiletine Therapy for Erythromelalgia. Arch Dermatol. 1999; 135(12):1447-1449. http://archderm.ama-assn.org/cgi/content/full/135/12/1447. Accessed 2/18/2008.
- Nardino RJ, Silber ALM. Erythromelalgia. eMedicine Journal. May 24, 2006; http://www.emedicine.com/med/TOPIC730.HTM. Accessed 2/18/2008.