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Genetic and Rare Diseases Information Center (GARD)

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Degos disease

Other Names for this Disease
  • Atrophic papulosis, malignant
  • Degos syndrome
  • Degos's malignant atrophic papulosis
  • Kohlmeier-Degos disease
  • Malignant atrophic papulosis
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How might Degos disease be treated?

Currently, there is not a targeted therapy for Degos disease that has been proven effective. Treatment of Degos disease has been attempted with antithrombotic agents, such as aspirin and dipyridamole.[1] These treatments were reported to be effective in some patients.[1][2] Other treatments that have been tried, but have shown inconsistent results, include anticoagulants and fibrinolytic agents (drugs to help break-up and dissolve clots), ticlopidine, pentoxifylline, prostaglandin E1, and interferon alpha-2a. Treatment with intravenous immunoglobulin has also been tried, but produced conflicting results.[2] Infliximab was reported to be ineffective in one case.[2] Immunosuppressives such as corticosteroids may worsen Degos disease.[2]

For further information on your treatment options, we encourage you to discuss your questions and this information with your healthcare provider.
Last updated: 10/26/2011

  1. Mark LA, Mirowski GW. Oral Disease and Oral-Cutaneous Manifestations of Gastrointestinal and Liver Disease. In: Feldman eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 9th ed. Philadelphia, PA: Saunders; 2010;
  2. Cheng TS. A man with generalized small white skin lesions and abdominal pain. Int J Dermatol. 2011 Jun;50(6):726-9; Accessed 10/26/2011.

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.