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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Degos disease


Other Names for this Disease

  • Atrophic papulosis, malignant
  • Degos syndrome
  • Degos's malignant atrophic papulosis
  • Kohlmeier-Degos disease
  • Malignant atrophic papulosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might Degos disease be treated?

Currently, there is not a targeted therapy for Degos disease that has been proven effective. Treatment of Degos disease has been attempted with antithrombotic agents, such as aspirin and dipyridamole.[1] These treatments were reported to be effective in some patients.[1][2] Other treatments that have been tried, but have shown inconsistent results, include anticoagulants and fibrinolytic agents (drugs to help break-up and dissolve clots), ticlopidine, pentoxifylline, prostaglandin E1, and interferon alpha-2a. Treatment with intravenous immunoglobulin has also been tried, but produced conflicting results.[2] Infliximab was reported to be ineffective in one case.[2] Immunosuppressives such as corticosteroids may worsen Degos disease.[2]

For further information on your treatment options, we encourage you to discuss your questions and this information with your healthcare provider.
Last updated: 10/26/2011

References
  1. Mark LA, Mirowski GW. Oral Disease and Oral-Cutaneous Manifestations of Gastrointestinal and Liver Disease. In: Feldman eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 9th ed. Philadelphia, PA: Saunders; 2010;
  2. Cheng TS. A man with generalized small white skin lesions and abdominal pain. Int J Dermatol. 2011 Jun;50(6):726-9; http://www.ncbi.nlm.nih.gov/pubmed/21595670. Accessed 10/26/2011.


Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
Other Names for this Disease
  • Atrophic papulosis, malignant
  • Degos syndrome
  • Degos's malignant atrophic papulosis
  • Kohlmeier-Degos disease
  • Malignant atrophic papulosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.