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Genetic and Rare Diseases Information Center (GARD)

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Cyclic neutropenia


Other Names for this Disease

  • Cyclic hematopoiesis
  • Neutropenia cyclic
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Overview

Cyclic neutropenia is a rare blood disorder characterized by recurrent episodes of abnormally low levels of neutrophils (a type of white blood cell) in the body. Neutrophils are instrumental in fighting off infection by surrounding and destroying bacteria that enter the body. Symptoms of cyclic neutropenia may include fever, a general feeling of ill health, and/or sores (ulcers) of the mucous membranes of the mouth. Individuals with low levels of neutrophils (neutropenia) are highly susceptible to recurrent infections.[1] Cyclic neutropenia may be inherited or acquired. Some cases are present at birth and appear to occur randomly for no apparent reason (sporadic). Inherited cases appear to be transmitted in an autosomal dominant fashion and caused by mutations in the ELANE gene.[2]
Last updated: 10/18/2011

References

  1. Boxer, LA. Neutropenia, Cyclic. National Organization for Rare Disorders (NORD). 2009; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/663/viewAbstract. Accessed 10/18/2011.
  2. Dale DC. ELANE-Related Neutropenia. GeneRevews. July 2011; http://www.ncbi.nlm.nih.gov/books/NBK1533/. Accessed 10/18/2011.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Cyclic neutropenia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Cyclic hematopoiesis
  • Neutropenia cyclic
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.