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Cramp-fasciculation syndrome

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Cramp-fasciculation syndrome is a rare condition of the muscles.  Individuals with this disease experience persistent muscle twitching (fasciculations) and cramping, which can lead to muscle discomfort, pain, or tiredness.  These symptoms are thought to be due to the overactivity of the associated nerves.  Muscles in the leg are most commonly affected, though this condition may involve several parts of the body.  Exercise often worsens symptoms.[1][2]  Cramp-fasciculation syndrome is believed to remain stable over time, meaning that it does not develop into a more serious disease.[2]
Last updated: 6/12/2013


  1. Jansen PH, van Dijck JA, Verbeek AL, Durian FW, Joosten EM. Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population. European archives of psychiatry and clinical neuroscience. 1991; 241:102-104. Accessed 1/22/2013.
  2. de Carvalho M, Swash M. Cramps, muscle pain, and fasciculations: not always benign?. Neurology. 2004; 63:721-723. Accessed 1/22/2013.
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