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Genetic and Rare Diseases Information Center (GARD)

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Cramp-fasciculation syndrome

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Your Question

What are the other diagnoses that physicians make when they are not familiar with cramp fasciculation syndrome? I myself was diagnosed with fibromylagia when they could not come up with anything else.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What are the differential diagnoses for cramp-fasciculation syndrome?

Muscle cramps and twitches (fasciculations) are common symptoms that often occur in otherwise healthy people.[1][2][3] In these cases the symptoms may be triggered by muscle overuse, dehydration, lack of nutrients in the diet, lack of blood flow to the muscles, side effect of medications or therapies, sleep apnea, or stress.[1][2][4] These symptoms come and go and rarely last for more than a few days.[2]

In addition to cramp-fasciculation syndrome, muscle cramps and twitching can also be due to an underlying nervous system disorder, such as amyotrophic lateral sclerosis, nerve injury, pinched nerve, muscular dystrophy, and spinal muscular atrophy.[1][2][3][5] Unlike cramp-fasciculation syndrome, nervous system disorders can also cause a loss or change in sensation, muscle wasting, and muscle weakness.[2] Autoimmune conditions, such as Isaac syndrome can also cause muscle twitching.[2]

Cramp-fasciculation syndrome by definition is a non-progressing, benign disease. If a person with cramp fasciculation syndrome experiences a worsening of symptoms, a careful evaluation to rule out other diagnoses is recommended.[3]
Last updated: 6/12/2013