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Genetic and Rare Diseases Information Center (GARD)

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Collagenous colitis

Other Names for this Disease
  • Microscopic colitis, collagenous type
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What are the signs and symptoms of collagenous colitis?

All individuals with collagenous colitis experience chronic, watery, non-bloody diarrhea which is what typically prompts individuals to seek medical attention.[1][2] Onset of diarrhea may occur gradually over time or may be sudden and abrupt.[3] Episodes of diarrhea may be intermittent and can occur over weeks, months or years.[3]

Other signs and symptoms that commonly occur in affected individuals include abdominal pain or cramping; flatulence; bloating; and weight loss.[2][3] Incontinence, urgency, nausea, vomiting and fatigue have also been reported.[3]

Some individuals with collagenous colitis experience spontaneous remission even without treatment; however, relapses can occur.[3]
Last updated: 6/21/2013

  1. Mahajan D, Goldblum JR, Xiao SY, Shen B, Liu X. Lymphocytic colitis and collagenous colitis: a review of clinicopathologic features and immunologic abnormalities. Adv Anat Pathol. January 2012; 19(1):28-38.
  2. Adriana Stoicescu, Gabriel Becheanu, Mona Dumbrava, Cristian Gheorghe and Mircea Diculescu. Mædica - a Journal of Clinical Medicine. 2012; 7(1):3-9. Accessed 6/20/2013.
  3. Colitis, collagenous. NORD. May 21, 2008; Accessed 6/21/2013.